Taconic Biosciences Adds New Humanized Immune System (HIS) Model to Its Portfolio For Immuno-Oncology Research

New huNOG-EXL EA Model Extends Study Windows Significantly

RENSSELAER, N.Y., Jan. 18, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of the huNOG-EXL EA (Early Access) humanized immune system (HIS) mouse. This product expands Taconic’s widely used HIS portfolio. huNOG-EXL EA significantly lengthens the study window during which a myeloid-lineage HIS mouse model can be used successfully.

Taconic’s huNOG-EXL models support human myeloid and lymphoid cells, making these mice especially useful for immuno-oncology research and other immune-related applications. With the longest lifespan of any myeloid-supportive HIS model, the original huNOG-EXL model (now called huNOG-EXL SA, or Standard Access) has been successfully applied in preclinical drug discovery research since 2016. The huNOG-EXL SA model is provided after a quality control step at 10 weeks post-engraftment. Feedback from users suggests research applications requiring particularly long study timelines or importation into regions with long quarantine periods present experimental and logistical hurdles that can limit the utility of the Standard Access (SA) model.

The new huNOG-EXL EA model removes those challenges by providing access to huNOG-EXL mice soon after engraftment, extending the useful study window. This makes the huNOG-EXL EA ideal for engraftment of slow-growing tumors, longer treatment paradigms, or various study customizations. Early access to an extended myeloid lineage model is also advantageous to researchers who face model importation quarantines, which would otherwise consume a significant portion of the useful study window for these mice. Because the huNOG-EXL EA model is shipped before an engraftment QC step is possible, it is made using cells from donors previously validated to engraft well so as to reduce the risk of engraftment failures.

“The huNOG-EXL EA model meets critical scientific needs for investigators performing immuno-oncology research or studying other immune-related diseases,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “After conducting extensive research and development, along with rigorous beta testing with several industry partners, Taconic is excited to now offer the new model and expand the usefulness of this unique humanized mouse.”

To learn more about Taconic’s huNOG-EXL EA model, please contact us at 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates three service laboratories and six breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Nancy J Sandy

CEO

608-332-6320

Nancy.Sandy@taconic.com

OKX overtakes global crypto exchanges as 2nd largest, rebrands as cross-platform services provider

Formerly OKEx, OKX’s new brand highlights the platform’s robust suite of crypto, NFT and DeFi investing products

VICTORIA, Seychelles, Jan. 18, 2022 (GLOBE NEWSWIRE) — OKX, which recently became the second largest cryptocurrency exchange in the world by spot trading volume, today announced a company-wide rebrand that reflects the dynamism and accelerating adoption of cryptocurrency. Founded in 2017 as a cryptocurrency trading service, OKX has since amassed over 20 million users and expanded its suite of digital asset investing products to include OKX Earn, a tool for earning passive crypto income; an NFT marketplace and decentralized application discovery hub; and most recently, MetaX, OKX’s new decentralized mode that features a cross-chain dashboard and self-custody Web 3.0 wallet for storing digital assets, including NFTs.

This shift, as highlighted by the company’s name change from OKEx to OKX, reflects the platform’s growing number of wealth creation opportunities beyond the exchange, which investors use to trade hundreds of digital assets on spot, margin and derivatives markets.

As part of the move, OKX has declared its mission to be “to remove barriers to wealth creation by giving you access to everything our decentralized future holds.” This underscores the platform’s ongoing evolution towards decentralization, which includes giving investors the option to self-custody their digital assets. Distinct from other centralized cryptocurrency exchanges, OKX is committed to gradually decreasing the company’s level of involvement in user activity, with the ultimate goal of shedding intermediation entirely.

“OKX is moving beyond the standard centralized exchange model to give our customers an end-to-end cryptocurrency experience,” said Jay Hao, CEO of OKX. “Most importantly, we’re doing this while upholding the core principles of crypto — decentralization and autonomy. Our goal is to give customers the tools they need to easily and securely earn, transfer, and spend their wealth as they see fit, without intermediation from us. We’ve dropped the ‘E’ from our name because we’re so much more than an exchange, just like crypto is so much more than a speculative asset.”

OKX, which lists over 250 digital assets and has long held the #1 rank for cryptocurrency futures trading volumes, recently became the second largest cryptocurrency spot trading platform in the world. In 2021, total trading volume on the platform, including spot and derivatives instruments, grew over 700%, while the number of trades executed on the platform increased over 480%. Staking, savings and DeFi offerings via OKX Earn saw over $5.1 billion deposited by users, and paid out over $314 million in passive income this past year.

To learn more, please visit OKX.com and follow @OKX on Twitter.

About OKX

Founded in 2017, OKX is a world leading cryptocurrency exchange and ecosystem. OKX has innovatively adopted blockchain technology to reshape the financial ecosystem and offers some of the most diverse and sophisticated products, solutions and trading tools on the market. Trusted by more than 20 million people in 180 regions across the globe, OKX’s mission is to remove barriers to wealth creation by offering access to everything the decentralized future holds. With its unwavering commitment to innovation, OKX envisions a world of financial inclusion for all through the power of crypto and decentralized finance.

Contact us

Email: media@okx.com
Olivia Capozzalo:
olivia.capozzalo@okx.com
@oliviacap (Telegram)

Good news for kung fu enthusiasts around the world – Shaolin Temple launches kung fu online games

DENGFENG, China, Jan. 18, 2022 /PRNewswire/ — With the Chinese New Year around the corner, China’s Songshan Shaolin Temple and Shaolin Culture Centers across the world have launched a global kung fu contest – “Happy Chinese New Year: Shaolin Kung Fu Online Games.”

“Shaolin kung fu boasts the value of fitness, enlightenment, and harmony,” said the abbot of the Shaolin Temple, Master Shi Yongxin. “As countries around the world battle the COVID-19 pandemic, the Shaolin Temple launched the competition online with the aspiration of promoting peace, friendship, and health, hoping that kung fu fans around the globe gain health, fitness, and happiness,” the abbot added.

The Shaolin Temple organizes year-end kung fu examinations for the monks at the end of each year to encourage kung fu monks to be more brave and diligent.

This year, the examination will be launched online for kung fu lovers of all ages across the globe. Participants will only need to upload a video to the official website of the activity.

The online kung fu games promote communication and interaction between people around the globe against the backdrop of epidemic curbing. The online games are not only an arena for global competitors but also a joyous “family reunion” of all kung fu enthusiasts.

The Chinese zodiac sign of 2022 is the Tiger, and the tiger represents justice, majesty, bravery, and diligence in Chinese culture, which identifies with the concept of Shaolin kung fu.

Shaolin Kung fu has a long history of more than 1,500 years and is one of China’s top-level martial art schools with a complete system. As a national intangible cultural heritage of China, Shaolin kung fu illustrates the desire for supernatural powers and the pursuit of extraordinary wisdom.

The Shaolin Temple has established Shaolin Culture Centers in more than 120 cities on five continents, with more than tens of millions of disciples. Former South African President Nelson Mandela praised Shaolin culture for the human values it instills. Moreover, Stephen Orlins, president of the National Committee on United States-China Relations recalled the legacy of the “ping-pong diplomacy” when talking about Shaolin kung fu, after watching a kung fu performance at the United Nations headquarters.

Registration for the games is now open until January 20 at 24:00, local time. Please visit the official website and App of the Shaolin Temple for more details.

Photo – https://mma.prnewswire.com/media/1728275/image_1.jpg

Covid-19: Angola reports 301 new infections, 285 recoveries

Luanda- At least 301 new cases, 285 patients recovered and four deaths are the results of the last 24 hours announced Tuesday by the Angolan health authorities.

According to the daily bulletin, 202 were diagnosed in Luanda, 37 in Huambo, 29 in Zaire, 11 in Benguela, 7 in Moxico, 6 in Huila, 5 in Bié, 3 in Lunda Sul and 1 in Lunda Norte.

Among the new cases whose ages range between 6 months and 88 years, 186 are male and 115 are female.

In the last 24 hours, 2,488 samples were processed by RT-PCR, with a positivity rate of 12.1 percent.

According to the bulletin, 126 of those recovered reside in Huambo, 57 in Benguela, 48 in Moxico, 14 in Lunda Norte, 13 in Bié, 13 in Lunda Sul, 6 in Huila, 5 in Luanda and 3 in Uige.

The deaths of three male citizens and one female citizen occurred in the provinces of Luanda, with three, and Benguela with one, respectively.

Angola has a cumulative number of 94,275 confirmed cases, of which 7,478 are active, 1,870 have died and 84,927 have been recovered.

Of the active cases, 5 are critical, 32 serious, 45 moderate, 71 light and 7 325 asymptomatic.

In the treatment centres, 153 patients are hospitalised, while 118 are serving institutional quarantine.

Source: Angola Press News Agency

US Telecom Carriers to Limit 5G Rollout Near Airports

Major U.S. telecommunications companies Verizon and AT&T agreed Tuesday to delay their deployment of new 5G mobile services around key airports after airline executives contended that the technology posed safety threats to airliners.

U.S. President Joe Biden said in a statement that the government’s agreement with the telecom companies would “avoid potentially devastating disruptions to passenger travel, cargo operations, and our economic recovery” while allowing them to deploy more than 90% of their wireless towers on Wednesday as they had planned.

“This agreement protects flight safety and allows aviation operations to continue without significant disruption,” Biden said, “and will bring more high-speed internet options to millions of Americans.”

The two telecom firms reached agreement with federal authorities after major U.S. air carriers warned Monday that the country’s commerce would “grind to a halt” if the 5G mobile technology were deployed near major airports. The White House did not say at how many airports the 5G technology is being delayed.

Biden thanked the mobile carriers for the delay and said negotiations would continue.

“My team has been engaging nonstop with the wireless carriers, airlines and aviation equipment manufacturers to chart a path forward for 5G deployment and aviation to safely coexist,” he said. “And, at my direction, they will continue to do so until we close the remaining gap and reach a permanent, workable solution around these key airports.”

The airlines say the new technology will interfere with safe flight operations, while the mobile carriers claim the airlines have known about the problem and failed to upgrade equipment on their aircraft to prevent flight problems.

The new high-speed 5G mobile service uses a segment of the radio spectrum that is close to that used by altimeters — devices in cockpits that measure the height of aircraft above the ground.

AT&T and Verizon argue that their equipment will not interfere with aircraft electronics and that technology is being safely used in many other countries.

In a letter Monday to Transportation Secretary Pete Buttigieg, chief executives at Delta Air Lines, American Airlines, United Airlines and seven other passenger and cargo carriers protested the mobile carriers’ plan to roll out their upgraded service on Wednesday.

While the Federal Aviation Administration previously said it would not object to deployment of the 5G technology because the mobile carriers had pledged to address safety issues, the airline executives said aircraft manufacturers subsequently warned them that the Verizon and AT&T measures were not sufficient to allay those concerns.

The mobile companies said they would reduce power at 5G transmitters near airports, but the airlines have asked that the 5G technology not be activated within 3.2 kilometers of 50 major airports. The details of the telecoms’ pullback around airports were not immediately known.

If the 5G technology is used, the airline executives contended, “multiple modern safety systems on aircraft will be deemed unusable. Airplane manufacturers have informed us that there are huge swaths of the operating fleet that may need to be indefinitely grounded.”

“Immediate intervention is needed to avoid significant operational disruption to air passengers, shippers, supply chain and delivery of needed medical supplies,” the airline industry executives said.

Source: Voice of America

Felony Charges Are a First in Fatal Crash Involving Autopilot

California prosecutors have filed two counts of vehicular manslaughter against the driver of a Tesla on Autopilot who ran a red light, slammed into another car and killed two people in 2019.

The defendant appears to be the first person to be charged with a felony in the United States for a fatal crash involving a motorist who was using a partially automated driving system. Los Angeles County prosecutors filed the charges in October, but they came to light only last week.

The driver, Kevin George Aziz Riad, 27, has pleaded not guilty. Riad, a limousine service driver, is free on bail while the case is pending.

The misuse of Autopilot, which can control steering, speed and braking, has occurred on numerous occasions and is the subject of investigations by two federal agencies. The filing of charges in the California crash could serve notice to drivers who use systems like Autopilot that they cannot rely on them to control vehicles.

The criminal charges aren’t the first involving an automated driving system, but they are the first to involve a widely used driver technology. Authorities in Arizona filed a charge of negligent homicide in 2020 against a driver Uber had hired to take part in the testing of a fully autonomous vehicle on public roads. The Uber vehicle, an SUV with the human backup driver on board, struck and killed a pedestrian.

By contrast, Autopilot and other driver-assist systems are widely used on roads across the world. An estimated 765,000 Tesla vehicles are equipped with it in the United States alone.

In the Tesla crash, police said a Model S was moving at a high speed when it left a freeway and ran a red light in the Los Angeles suburb of Gardena and struck a Honda Civic at an intersection on December 29, 2019. Two people who were in the Civic, Gilberto Alcazar Lopez and Maria Guadalupe Nieves-Lopez, died at the scene. Riad and a woman in the Tesla were hospitalized with non-life-threatening injuries.

Criminal charging documents do not mention Autopilot. But the National Highway Traffic Safety Administration, which sent investigators to the crash, confirmed last week that Autopilot was in use in the Tesla at the time of the crash.

Riad’s defense attorney did not respond to requests for comment last week, and the Los Angeles County District Attorney’s Office declined to discuss the case. Riad’s preliminary hearing is scheduled for February 23.

‘Automation complacency’

The National Highway Traffic Safety Administration and the National Transportation Safety Board have been reviewing the widespread misuse of Autopilot by drivers, whose overconfidence and inattention have been blamed for multiple crashes, including fatal ones. In one crash report, the NTSB referred to its misuse as “automation complacency.”

The agency said that in a 2018 crash in Culver City, California, in which a Tesla hit a firetruck, the design of the Autopilot system had “permitted the driver to disengage from the driving task.” No one was hurt in that crash.

Last May, a California man was arrested after officers noticed his Tesla moving down a freeway with the man in the back seat and no one behind the steering wheel.

Teslas that have had Autopilot in use also have hit a highway barrier or tractor-trailers that were crossing roads. NHTSA has sent investigation teams to 26 crashes involving Autopilot since 2016, involving at least 11 deaths.

Messages have been left seeking comment from Tesla, which has disbanded its media relations department. Since the Autopilot crashes began, Tesla has updated the software to try to make it harder for drivers to abuse it. The company also tried to improve Autopilot’s ability to detect emergency vehicles.

Tesla has said that Autopilot and a more sophisticated Full Self-Driving system cannot drive themselves and that drivers must pay attention and be ready to react at any time. Full Self-Driving is being tested by hundreds of Tesla owners on public roads in the U.S.

Bryant Walker Smith, a law professor at the University of South Carolina who studies automated vehicles, said this is the first U.S. case to his knowledge in which serious criminal charges were filed in a fatal crash involving a partially automated driver-assist system. Tesla, he said, could be “criminally, civilly or morally culpable” if it is found to have put a dangerous technology on the road.

Donald Slavik, a Colorado lawyer who has served as a consultant in automotive technology lawsuits, including many against Tesla, said he, too, is unaware of any previous felony charges being filed against a U.S. driver who was using partially automated driver technology involved in a fatal crash.

Lawsuits against Tesla, Riad

The families of Lopez and Nieves-Lopez have sued Tesla and Riad in separate lawsuits. They have alleged negligence by Riad and have accused Tesla of selling defective vehicles that can accelerate suddenly and that lack an effective automatic emergency braking system. A joint trial is scheduled for mid-2023.

Lopez’s family, in court documents, alleges that the car “suddenly and unintentionally accelerated to an excessive, unsafe and uncontrollable speed.” Nieves-Lopez’s family further asserts that Riad was an unsafe driver, with multiple moving infractions on his record, and couldn’t handle the high-performance Tesla.

Separately, NHTSA is investigating a dozen crashes in which a Tesla on Autopilot ran into several parked emergency vehicles. In the crashes under investigation, at least 17 people were injured, and one person was killed.

Asked about the manslaughter charges against Riad, the agency issued a statement saying there is no vehicle on sale that can drive itself. And whether or not a car is using a partially automated system, the agency said, “every vehicle requires the human driver to be in control at all times.”

NHTSA added that all state laws hold human drivers responsible for the operation of their vehicles. Though automated systems can help drivers avoid crashes, the agency said, the technology must be used responsibly.

Rafaela Vasquez, the driver in the Uber autonomous test vehicle, was charged in 2020 with negligent homicide after the SUV fatally struck a pedestrian in suburban Phoenix in 2018. Vasquez has pleaded not guilty. Arizona prosecutors declined to file criminal charges against Uber.

Source: Voice of America

Angola analyses cooperation with Congo

Luanda – Angola and the Republic of Congo on Tuesday discussed strengthening friendship and bilateral cooperation in several areas at a meeting in Brazzaville.

The Angolan Foreign Ministry said in a statement that the analysis was made during a meeting between the head of Angolan diplomacy, Teté António, and the Minister for Foreign Affairs, the Francophony and Congolese Abroad of the Republic of Congo, Jean-Claude Gakosso.

At the meeting, held on the eve of the Conference of Heads of State and Government of the Economic Community of Central African States (ECCAS), the two entities addressed, in particular, the holding of the next Joint Commission of cooperation between the two countries.

On the multilateral front, the two ministers discussed the results achieved by ECCAS during the current presidency of the Republic of Congo.

The interlocutors reaffirmed the will of both countries to continue contributing to the implementation of the ECCAS reform, in order to make the ideal of regional economic integration more effective, in favour of the welfare and prosperity of the community’s population.

Source: Angola Press News Agency

CPLP ministers evaluate cooperation

Luanda – Angola is this Wednesday, hosting the 9th meeting of ministers of Science, Technology and Higher Education of the Community of Portuguese-speaking Countries (CPLP), with the aim of boosting cooperation in the sector.

In a press release, the Angolan Ministry for Higher Education, Science, Technology and Innovation said that the event would assess the implementation degree of the Strategic Plan for Multilateral Cooperation for 2014 and 2020, as well as approve a new political agenda for 2026.

Proposals for projects and programmes for intra- and extra-community multilateral cooperation in science, technology and higher education in the CPLP and cooperation between this community and international organisations, as well as civil society, will also be analysed.

Also under debate will be the issue related to “the digital and science in post-Covid-19 societies: challenges and perspectives”.

Source: Angola Press News Agency

President João Lourenço unveils digital incubator for companies

Luanda – The President of the Republic, João Lourenço, Tuesday, inaugurated the facilities of Digital.ao, where the Technological Incubator will operate, an infrastructure that aims to help transform innovative ideas from young Angolans into productive and sustainable businesses (companies).

After the formal cutting of the ribbon, the Head of State, accompanied by members of the Government, watched an institutional video of the project, visited some service areas of the infrastructure and received information about the functioning of the installed equipment.

The facility is located in the CTT area, in the urban district of Rangel, in the municipality of Luanda, and the technological incubator also aims to promote small, medium and large companies.

Digital.ao is budgeted at around 1.3 billion kwanzas, and the construction of the infrastructure started in 2016, but, for objective reasons, was paralyzed, having resumed in 2019.

Financed with ordinary resources from the treasury and with the sector’s own resources, the construction of Digital.ao also had the support of partners such as Huawei, Afrione, the African Development Bank and the World Bank.

Digital.ao has an infrastructure made up of two buildings. The first one has three floors and includes multifunctional spaces, a videoconference room, a computer repair laboratory and a software factory.

The second building, with one floor, is aimed at technical and professional qualifications, has, in addition to other compartments, rooms specializing in repair, maintenance and configuration of computers, printers and mobile phones, as well as analog, digital and robotics electronics.

Source: Angola Press News Agency

New Police chief sworn in

Luanda – The President of the Republic, João Lourenço, Tuesday in Luanda said that it is the State’s responsibility to ensure that citizens exercise in freedom the rights conferred on them by the Constitution and the Law.

On swearing in the new commander-general of the National Police, Arnaldo Manuel Carlos, the President of the Republic said that it was also the State’s responsibility to ensure public order and tranquillity for citizens, with the assistance of different bodies.

João Lourenço said he was confident that the new commander-general of the National Police would carry out his duties with dignity, professionalism and in a competent manner, and assured him of the necessary assistance for that purpose.

Before his swearing in, Arnaldo Manuel Carlos was graduated to the rank of Commissioner General of the National Police, by the President of the Republic, as Commander-in-Chief.

At the end of the ceremony, the Commissioner-General pointed out as priorities the fight against crime and the increase of the sense of security of the population, with the participation of the citizens.

He said that fighting crime with professionalism, under the terms of the law and respecting the rights and freedoms of citizens, was one of the recommendations received.

For the current year, he pointed as priorities the securing of the next elections, scheduled for August, and other acts in the political calendar.

Source: Angola Press News Agency